28 May, 2009

Give us your feedback!

Hello all,

We are curious as to how our users are finding the current Ensembl web browser. We opened a survey in the current Ensembl (version 54). The survey will close in one week's time (Friday, 5 June). Thank you to everyone who has already entered their feedback.

For users who have not yet replied to the survey, we ask that you spare 10 minutes or so of your time to do so. Please give us your thoughts and feedback by clicking on the link below:

http://tinyurl.com/cv67vs

The feedback centers on the web browser, specifically the new interface launched in Nov, 2008.

Many thanks for your time.

Regards,
The Ensembl Team

21 May, 2009

Ensembl Events in June 2009

For June we have the following Ensembl events:

4-5 June : Browser workshop at the University of Cambridge, Cambridge, UK
11 June: Demo for the National Genetics Reference Lab, Manchester, UK
15-16 June: Browser workshop at the Facultad de Ciencias de la Universidad de Los Andes, Mérida, Venezuela
18-19 June: Developers workshop at the Facultad de Ciencias de la Universidad de Los Andes, Mérida, Venezuela
22 June: Browser workshop for NHS Molecular Genetics Laboratories at Liverpool Women's Hospital, Liverpool, UK
24-26 June: Ensembl module in the Bioinformatics for Vascular Biology course at the EBI, Hinxton, UK
29 June: Browser workshop at the Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany

For details about these and other upcoming events, please have a look at the complete list of Ensembl training events.

15 May, 2009

Pre, Archive, and Vega downtime

Next week, 18-24 May, an upgrade is scheduled that will affect the following sites:

Archive sites versions 48-53 (Dec 2007-May 2009) (Downtime will start Monday 18 May)

BLAST and User Upload on Pre! sites (Wednesday 20 May)

BLAST and User Upload on the Vega site

We ask our users to plan to use these sites after the upgrade, if possible.

Regards,
The Ensembl Team

14 May, 2009

Ensembl 55

We are currently working on our next release which is due at the end of June 2009 and will contain the following:

Data

Human GRCh 37
We will be releasing a new genebuild for human based on the lastest assembly GRCh37 from the Genome Reference Consortium. A preliminary version of this assembly is available now in Ensembl Pre! Due to the new assembly we will have:
  • Updated repeat masking
  • New probeset mappings
  • cDNA update
  • A new ensembl-vega merge delivering a new gene set
Wallaby
Ensembl 55 includes the 2X genome for Tammar Wallaby (Macropus eugenii), this will be a projection build similar to our other 2X species.

C. elegans
We will also include an import of the WormBase release WS200 database for C. elegans.

Anole lizard - A gene patch incorporating the gene set provided by Chris Ponting at Oxford University means that we have a new gene set for the green anole lizard (Anolis Carolinensis).

Mouse - The mouse cDNA alignments have been updated.

Zebrafinch - There will be an updated gene set for the 6X zebra finch genome.

Zebrafish - Non-coding RNAs will be added to the Zv8 zebrafish assembly and there will also be some changes to protein coding gene models and new repeats and expression patterns.

Core

Schema Changes
  • Patch to update versions (patch_54_55_a.sql). * Add the missing types to go_xref (patch_54_55_b.sql).
  • Add new table dependent_xref (will hold the dependencys for the xrefs, i.e. if an EMBL entry come from a uniprot entry this relationship will be in the table)( patch_54_55_d.sql).
  • Add new tables for alternative splicing/transcript events (patch_54_55_c.sql).
  • Add new column 'is_constitutive' to the exon table (patch_54_55_e.sql)

Xrefs
Xrefs will be run for Human, Macacca, Opossum, Chimp, Chicken, Dog and Mouse (including Fantom Xrefs).

Ontology database schema and tools
The ensembl_go_NN databases are no longer being built. Instead we are replacing this with the ensembl_ontology_NN database which may be connected to using the core API.

Assembly mapping
Some of the databases will contain mapping coordinates between current and previous assemblies:
  • human: mapping from current GRCh37 to NCBI36, NCBI35 and NCBI34
  • mouse: mapping from current NCBIM37 to NCBIM36, NCBIM35 and NCBIM34
Other changes
  • API support for alternative transcripts/splicing events will be added
  • API support for constitutive exons will be added
  • Deprecated API modules will be removed
  • All slices will be created using the new_fast method from the SliceAdaptor to improve performance
  • seq_region seq edit support will be added. Seq_edits can already be stored and retrieved but these were not used in getting the sequence data. This will be changed so that "_rna_edit" attributes in the seq_region_attrib table will be used and the sequence changed.
  • MySQL and FASTA dumps will be copied to Amazon Public Datasets project
  • Gene name and xref projections

Mart
  • New functional genomics mart * A new Probe section added to Ensembl mart
  • New ontology mart
  • Constitutive exon information will be re-added to Ensembl mart

Variation
  • There will be a new human variation database generated by mapping NCBI36 coordinates to GRCh37 (using dbSNP 129)
  • Illumina array data for SNP/CNV is to be added
  • Transcript variations for Zebrafish and Zebrafinch will be reculated to include information from the new gene sets
  • Schema change - added a call to get consequence_type
Functional genomics
  • Human Regulatory Build will be updated using the GRCh37 assembly
  • Probe alignment and transcript annotation for all species will migrate from the core datbases to the functional genomics databases, this includes Affymetrix, Illumina, Codelink and Phalanx
  • Schema change, an is_current filed is to be added to the coord_system table
Comparative genomics

Alignments - The new human assembly means that the following alignments will be regenerated:
  • 9 eutherian mammals EPO multiple alignments
  • 31 eutherian mammals EPO multiple alignments
  • 12 amniota vertbrates Pecan multiple alignments
  • 4 catarrhini primate EPO multiple alignments
  • Pairwise BLASTZ-NET alignments of human against each of the other 9 and 31 eutherian mammals
  • Additional pairwise BLASTZ-NET alignments will be run for human-opossum, human-platypus, human- chicken and human-wallaby
  • Translated BLAT-NET will be regenerated for human against fugu, X.tropicalis, C.intestinalis, C.savignyi, stickleback, medaka, chicken, zebrafish, tetraodon, zebrafinch and anole lizard

Synteny will be recalculated for: rat vs. huamn, chicken vs. human and human vs. macaque, dog, chimpanzee, platypus, opossum, mouse, orangutan, horse and cow

Homologies amd families
  • 50 way GeneTrees and homologies with new/updated genebuilds and assemblies
  • Clustering using hcluster_sg
  • Multiple Sequence Alignments using consistency-based MCoffee meta-aligner (mafftgins + muscle + kalign + probcons) and new exon-skipping aware "skipper" algorithm.
  • New 'putative gene split' and 'distant paralog' homology types
  • Pairwise gene-based dN/dS calculations for high coverage species pairs
  • Updated MCL families including all Ensembl transcript isoforms and newest Uniprot Metazoa
  • Multiple sequence alignments with MAFFT
  • Stable IDs for GeneTrees (ENSGT00550NNNNNNNNN) and MCL Families (ENSFM00550NNNNNNNNN).





12 May, 2009

SNPs and ancestral alleles


The new Ensembl release includes a new view for SNPs and other genomic variations. It shows the alignment of the polymorphic position together with 10 base pairs of sequence up- and downstream. The user can choose among all available multiple alignments. Polymorphic positions in the other species are also shown.

This is very useful for looking at ancestral alleles, especially in combination with our EPO alignments as they include the inferred ancestral sequence. Although dbSNP provide predicted ancestral alleles for human SNPs, these are based on the chimp sequence only. In several cases, the ancestral sequence inferred from the multiple alignment is in disagreement with the chimp sequence like in this example. Using multiple alignments gives better results and more confidence to the calls.

08 May, 2009

Release 54 and pre.ensembl.org

The Ensembl project is pleased to announce release 54 of Ensembl. Highlights of this release are:

  • New Zv8 zebrafish assembly;
  • Comparative alignment text displays for variations and regions;
  • Ability to add personal notes to any Gene or Transcript.
For more information visit:
Along side this release we are also releasing a new version of the pre site. This now includes:

05 May, 2009

The eFG Array Mapping Environment

The Ensembl Functional Genomics (eFG) environment has been expanded to incorporate array mapping functionality. Historically, arrays from different vendors have been processed in similar, but non-identical ways due to differing array designs, with the output being stored in the core database. The 'arrays' environment unifies this process within the eFG database to provide a new standardised array mapping procedure for all array formats. This involves a two step process whereby probe sequences are aligned both to genomic and transcript sequences, and then subsequently transcripts are annotated with xrefs(DBEntries) dependant on the quality of the probe alignments around a given transcript locus.

The 'arrays' environment provides easily accessible and interactive command line functions to help run and administer the array mapping pipeline. Recent developments include broader array format support and multi-species capability, along with capture of much more detailed mapping information. This data has yet to be seen in the Ensembl browser, but from release 55 we will start redirecting the web displays to use the eFG data, with a view to developing a more detailed 'Probe' panel at some point later in the year.

We will endeavour to provide alignments and mappings of all popular arrays, for all others we invite you to try out the eFG 'arrays' environment. For more information check out(literally):

ensembl-functgenomics/docs/array_mapping.txt

Or see it online here.

If you have any questions, please mail ensembl-dev@ebi.ac.uk

02 May, 2009

Browser Training in Vienna on 22 May

The Ensembl Genome Browser project is pleased to announce a workshop on 22 May as a satellite meeting of the European Human Genetics Conference in Vienna, Austria. This full-day workshop is aimed at geneticists and life scientists, and will explore genes, variations, and comparative information using the browser's new interface released Nov, 2008. An introduction to large-scale data retrieval with BioMart will be included. We will also feature brief introductions into the European Genotype Archive (EGA) and the 1000 Genomes Project. The format of our browser workshops are described on our outreach page.

The course on 22 May is held at a central location- the Vienna University Computer Service.

The workshop is free, however limited places are available. Please register if you will be attending.

23 April, 2009

Ensembl Events in May 2009

For May we have the following Ensembl events:

29 April - 1 May: Ensembl Developers workshop at the University of Cambridge, Cambridge, UK
8 May: Browser workshop at Imperial College, London, UK
11-13 May: Ensembl module in the Wellcome Trust Open Door Workshop - Working with the Human Genome Sequence, Hinxton, UK
11-15 May: Ensembl module in the EBI hands-on training A walktrough EBI Bioinformatics Resources, Hinxton, UK
12-13 May: Ensembl module in the EBI roadshow at the Université Victor Segalen Bordeaux 2, Bordeaux, France
19-21 May: Ensembl module in the EBI roadshow at the Universidade de Santiago de Compostela, Santiago de Compostela, Spain
22 May: Browser workshop at the European Human Genetics Conference, Vienna, Austria
26 May: Ensembl Developers workshop at the VIB Flanders Interuniversity Institute of Biotechnology, Ghent, Belgium
27-28 May: Browser workshop at the Erasmus MC Molecular Medicine Postgraduate School, Rotterdam, The Netherlands

For details about these and other upcoming events, please have a look at the complete list of Ensembl training events.

20 April, 2009

Ensembl Genomes live!

Today the long-awaited Ensembl Genomes went live! This is a 'sister project' focusing on those species that aren't part of Ensembl, i.e. non-vertebrates. Please have a look at what the Ensembl Genomes team have to say about it themselves:

"We are delighted to announce the forthcoming release of Ensembl Bacteria, Ensembl Protists and Ensembl Metazoa, the first sites to be launched as part of the EBI's "Ensembl Genomes" project to extend the use of the Ensembl browser to non-vertebrate genomes.

These following site are available:

http://bacteria.ensembl.org
http://protists.ensembl.org
http://metazoa.ensembl.org

Additional sites for fungi and plants are in development and will be launched during the summer of this year.

In the Ensembl Genomes project, we are aiming to do two things: firstly to work with particular communities to support the bioinformatic analysis of genome-scale data; and secondly, to provide an integrative portal to data from species of scientific interest from across the taxonomic space. In pursuit of both these aims, we will re-use and extend the proven Ensembl software system, that has been developed by EBI and the Wellcome Trust Sanger Institute in the context of vertebrate genomics.

As with Ensembl, Ensembl Genomes will provide access to DNA and protein sequence, positional and functional annotation of protein-coding and non-protein coding genes, repeat analysis and other features and statistics. An interesting feature made available with the release of Ensembl Genomes is the inclusion of a multi-way comparative genomic analysis performed using a selection of species from bacteria to humans, and the production of gene trees showing the inferred ancestral relationships within deeply conserved protein families. Comparative resources are also provided at a narrower level (for example, DNA and protein-based analyses of individual bacterial clades). In partnership with collaborators, we are working on capturing gene expression, and population-scale variation data, in a number of contexts. More generally, we anticipate the ongoing enrichment of these resources through the integration of increasing quantities of high throughput data now becoming routinely available for all species.

Ensembl Genomes will provide access to data through the usual routes supported for vertebrate data; web-based browser, FTP site, programmatic API, DAS, and BioMart-style data warehouse; as well as text and sequence-based search.

We look forward to working with you as future producers and consumers of data. More information about the project is available at http://www.ensemblgenomes.org. We will be happy to receive any feedback you might wish to offer us at helpdesk@ensemblgenomes.org."

03 April, 2009

Ensembl Tips: Navigating the Browser




Though the overall response has been good, a few Ensembl users are finding it difficult to switch from the old interface to the new browser launched Nov, 2008. For those users, functionality has not been lost. You should still be able to do the same tasks as before in a faster interface.

We will post a series of tips to show you how to make the switch from the old interface to the new. If you still have trouble, please watch our video tutorial: Browsing Ensembl.

TIP: I want to use ExonView. Where is this now?

To view the full genomic sequences, exons and introns, go to any transcript. (Exons are transcript information. To see the exons page, go to a transcript tab, not the gene tab.) Click on the 'Exons' link under 'Sequence' at the left of any transcript page.

To show the full introns, click on 'Configure this page' at the left. Select 'Show full intronic sequence'. Click 'Save and Close' at the top right corner of the menu window.

Still can't find what you're looking for? Email us at helpdesk@ensembl.org.

26 March, 2009

Ensembl Events in April 2009

For April we have the following Ensembl events:

31 March - 1 April : Browser workshop at the IGC, Oeiras, Portugal
2-3 April: Ensembl Developers workshop at the IGC, Oeiras, Portugal
16 April: Demo for the National Genetics Reference Lab, Manchester, UK
17 April: Browser workshop at Imperial College, London, UK
22 April: Browser workshop at Imperial College, London, UK *postponed to 8 May*
27-29 April: Ensembl module in the EBI roadshow at the University of Iceland, Reykjavik, Iceland
27-29 April: BioMart module in the EBI hands-on training Programmatic Access to Biological Databases (Java), Hinxton, UK
29 April - 1 May: Ensembl Developers workshop at the University of Cambridge, Cambridge, UK

For details about these and other upcoming events, please have a look at the complete list of Ensembl training events.

05 March, 2009

New Release (53)!


Ensembl just updated the live site and underlying databases to
version 53.

Some new features include 'Active Tracks' and a searchable 'Configure this page'!


Go to any region of the chromosome.

Click 'Configure this page' at the left.

'Active tracks' allows you to see (and deselect) all tracks that are turned on.

'Search display' allows you to search for tracks in the menus. In this example, we searched for UniProt. Tracks from different menus appear.

For more updates, including new species, variations, and Amazon Web Services, see the news.

27 February, 2009

Ensembl 54

We are already working on our next release (out late in April 2009) which will come with the following:

Data

Zebrafish
We will be releasing a new genebuild for zebrafish (with updated repeat masking) based on the latest assembly Zv8. Thus, we'll have a new gene set (with new probeset mappings).

Horse
A gene patch (fixing split genes) based on human/mouse 1:1 orthologues. Therefore we have a new gene set.

Human

  • cDNA update
  • New ensembl-vega merge delivering a "new gene set".
Mouse
  • cDNA update
  • New ensembl-vega comparison, delivering a "new gene set" .
New gene sets (ncRNA genes) for several low coverage genomes:
Sloth (Choloepus hoffmanni), armadillo (Dasypus novemcinctus), kangaroo rat (Dipodomys ordii), elephant (Loxodonta africana), hyrax (Procavia capensis), megabat (Pteropus vampyrus), tarsier (Tarsius syrichta), dolphin (Tursiops truncatus) and alpaca (Vicugna pacos).

Mart
  • New functional genomics mart
Core
Minor schema changes

  • cDNA update
  • Update versions (patch_53_54_a.sql)
  • Increase size of oligo_probe.name (patch_53_54_b.sql)
  • Increase size of external_db.db_name (patch_53_54_c.sql)
  • Move analysis_id from identity_xref to object_xref (patch_53_54_d.sql)
  • Increase size of analysis.logic_name (patch_53_54_e.sql)

Variation and Functional Genomics

  • Schema change to source table to add description column for web display
  • Updated zebafish database
  • Import Illumina data whenever available
  • Recalculate consequence type for mouse regulatory feature
  • eFG array mapping: Human, Mouse, Rat, Drosophila
  • Affymetrix (UTR/IVT + ST), Illumina (WG)
New mouse DNAse data to support the first Mouse RegulatoryBuild

Code Other

  • Amazon EC2 public datasets updated
  • New GO database (ensembl_ontology_54) and API
  • Changing default behaviour of TranscriptAdaptor
  • Translation attribs modified
  • Remove entries with spaces from species.classification
  • Gene name and xref projections

Pairwise alignments

Update the pairwise alignments for zebrafish (Danio rerio):

  • human-zebrafish translated BLAT-NET
  • mouse-zebrafish translated BLAT-NET
  • rat-zebrafish translated BLAT-NET
  • chicken-zebrafish translated BLAT-NET
  • frog-zebrafish translated BLAT-NET
  • tetraodon-zebrafish translated BLAT-NET
  • fugu-zebrafish translated BLAT-NET
  • medaka-zebrafish translated BLAT-NET
  • stickleback-zebrafish translated BLAT-NET
  • Ciona savignyi-zebrafish translated BLAT-NET
  • Ciona intestinalis-zebrafish translated BLAT-NET
Add new alignments for medaka:
  • human-medaka BLASTZ-NET (imported from UCSC)
  • mouse-medaka BLASTZ-NET (imported from UCSC)

The following files will be available for download:

  • EMF dumps for GeneTrees
  • EMF dumps for EPO and PECAN multiple alignments
  • BED files for 31 way GERP constrained elements
  • BED files for 12 way GERP constrained elements
Homologies and families
  • 49-way GeneTrees and Homologies, with new/updated gene sets and assemblies.
  • Multiple Sequence Alignments with consistency-based MCoffee
  • Meta-aligner (mafftgins+muscle+kalign+probcons).
  • Pairwise gene-based dN/dS calculations for high coverage species pairs.
  • Updated MCL families including all Ensembl AS isoforms and latest UniProt Metazoa.
  • Multiple Sequence Alignments with MAFFT


17 February, 2009

Ensembl Workshops in March, 2009

In March, explore Ensembl in the following events:

1-3: Presentation at the EURATools Annual meeting in Barcelona
5,6: Browser workshop at the Department of Genetics in Cambridge, UK
10: Browser workshop in Leuven, Belgium
13: Browser workshop at the Faculty of Science, Montevideo, Uruguay
16-19: Ensembl Module in the Open Door Workshop, Montevideo, Uruguay
19: Demo at the Bioinformatics Course, National Genetics Reference Lab, Manchester, UK
20: Browser workshop at the Max Delbrück Center in Berlin, Germany
31: Browser workshop at King's College, London, UK
31 March, 1 April : Demo and Browser Workshop at the IGC Oeiras, Portugal
2,3 April: Ensembl API workshop at the IGC, Oeiras, Portugal

Check out microorganisms at Ensembl genomes featured in the EBI 'Sequence to Genes' Workshop, EBI, Hinxton, UK

For details about these and other upcoming workshops, please have a look at the complete list of Ensembl training events.

25 January, 2009

Upcoming workshops February 2009

In February we will have the following Ensembl workshops:

10 Feb: Browser workshop at the Institute for Animal Health in Pirbright
11 Feb: Browser workshop at the Institute of Molecular Genetics in Prague, Czech Republic
12 Feb: Developers workshop at the Institute of Molecular Genetics in Prague, Czech Republic
23 Feb: Ensembl module in the EBI Roadshow at the Cyprus Institute of Neurology & Genetics in Nicosia, Cyprus
24-25 Feb: Developers workshop at the e-Science Centre in Edinburgh
26 Feb: Browser workshop at the Institute for Animal Health in Compton

For details about these and other upcoming workshops, please have a look at the complete list of Ensembl training events.

21 January, 2009

How to get all the orthologous genes between two species

Many users ask us about how to download data from ensembl. Usually, the answer is using BioMart. Comparative genomics data are also available in the standard Mart for your favorite species. For instance to get all the human-mouse orthologs, one can select the human dataset, filter all the genes with no mouse orthologs and choose to output the mouse orthologs for all the resulting genes.

Here is how to get these data in 10 simple steps
1. Go to: http://www.ensembl.org/biomart/martview
2. Choose "Ensembl 52"
3. Choose "Homo sapiens genes (NCBI36)"
4. Click on "Filters" in the left menu
5. Unfold the "MULTI SPECIES COMPARISONS" box, tick the "Homolog filters" option and choose "Orthologous Mouse Genes" from the drop-down menu.
6. Click on "Attributes" in the left menu
7. Click on "Homologs"
8. Unfold the "MOUSE ORTHOLOGS" box and select the data you want to get (most probably the gene ID and maybe the orthology type as well).
9. Click on the "Results" button (top left)
10. Choose your favorite output

Here is the preview of the results:



Other people may prefer to use our Compara Perl API or get the data directly from the Compara DB. These options are also available.

13 January, 2009

Extending Ensembl

Following a recent thread in our ensembl-dev mailing list, we can point our users to a recent post in the Gramene blog (a resources for grass genomes maintained at CSHL). This framework extends Ensembl with a data resource to browse several plant species: maize (Zea mays), rice (Oryza glaberrima and Oryza rufipogon), sorghum (Sorghum bicolor), the model organism Arabidopsis thaliana, grape (Vitis vinifera), and poplar (Populus trichocarpa); with comparative maps for additional species such as wheat (Triticum aestivum), barley (Hordeum vulgare) and oat (Avena sativa).

You can find some sample scripts to load an Ensembl species database from scratch, here.

Thanks to our colleagues at Gramene.

11 January, 2009

Ensembl Website road map...

We hope you like the new Ensembl website - we have had quite a lot of feedback about the system, and are digesting this to see how and where we can make the site more easy to use.

Missing features

We know there are a number of features which were in the webcode prior to the revamped version 51 that we are working on.

Views:
  • AlignSliceView [target e!53]
  • MultiContigView [target e!54]
  • CytoDump [will be released in e!53 as part of the export module]
  • DotterView
  • HistoryView - "ID liftover" [target e!53/4]
  • AssemblyConverter - "location liftover" [target e!53/4]
Components:
  • Drawing code tracks, e.g. rat QTLs, protein co-ordinate based DAS tracks [target e!53]
  • User gene annotations [target e!54]
New developments

We have a number of new "web" developments in the pipeline - some of these are listed below:
  • Extended configuration panel - searching for tracks, show currently active etc [target e!53]
  • Extended configuration panel - re-ordering tracks etc [target e!53]
  • Extended configuration panel - further configuration options - colour, depth, more display options, label options [target e!54/5]
  • New BLAST/BLAT interface [target e!55/6]
  • Re-write of the vertical drawing code to allow high quality PDF/PS/SVG karyotype and chromosome images to be produced.
  • Further work on export - finer configuration of what to export, exporting in multi-regions, integration with "user data"

09 January, 2009

Ensembl 53

We are already working on our next release (out late in February 2009) which will come with the following:

Data

  • New species added to our set: sloth (Choloepus hoffmanni), Anolis lizard (Anolis carolinensis) and zebrafinch (Taeniopygia guttata).
  • Updated marker information for human, cow, dog, horse, chicken, macaque, mouse and Medaka.
  • Updated manual annotation for mouse from VEGA.
Comparative Genomics
  • Pairwise alignments with the new species (human/sloth, zebrafinch/chicken, lizard/chicken).
  • New 31-way eutherian mammal alignment using these 2x genomes (based on the 9-way Enredo-Pecan-Ortheus multiple alignments): elephant (Loxondonta africana) , armadillo (Dasypus novemcinctus), tenrec (Echinops telfairi), rabbit (Oryctolagus cuniculus), guinea pig (Cavia porcelus), hedgehog (Erinaceus europaeus), shrew (Sorex araneus), microbat (Myotis lucifugus), tree shrew (Tupaia belangeri), squirrel (Spermophilus tridecemlineatus), bushbaby (Otolemur garnetii), pika (Ochotona princeps), mouse lemur (Microcebus murinus), cat (Felis catus), megabat (Pteropus vampyrus), dolphin (Tursiops truncatus), alpaca (Vicugna pacos), kangaroo rat (Dipodomys ordii), hyrax (Procavia capensis), tarsier (Tarsius syrichta), gorilla (Gorilla gorilla) and sloth (Choloepus hoffmanni).
  • The current clustering will be replaced by a hierarchical clustering sparse graphs (hcluster) for our trees.
Variation and Functional Genomics
  • An improved array mapping environment integrates genomic and cDNA mappings, supporting multi-species databases.
  • We'll link to Genome Wide Association from the NHGRI catalogue (Hindorff et al.)
  • Genotype data for mouse (reference strain C57BL/6) will be included.
  • Update of variation for dog, chicken and platypus.
Other